The Role of Bone Scintigraphy and Parathyroid Scintigraphy on Multiple Osteolytic Lesions Which Misdiagnosed as Primary Bone Tumor (Giant Cell Tumor)
Abstract
Brown tumor is a non-neoplastic lesion that resulting from abnormal bone metabolism. It can be manifest in prolonged or untreated hyperparathyroidism. The clinical symptoms, radiological and histopathological examination were similar with giant cell tumor and can be mimicking metastases; or even misdiagnosed with giant cell tumor and mistreated the patient. Biochemical examination of calcium levels and parathyroid hormone should be included in the routine assessment of patients with multiple osteolytic lesions. A multidiscipline approach is needed.Throughout this case report, we would like to report the important role of Nuclear Medicine and Molecular Theranostic imaging modality in 38-year-old male with multiple osteolytic lesions, which was first diagnosed as giant cell tumor and differential diagnosis bone metastases but turnout to be a metabolic bone disease (brown tumor) with parathyroid adenoma as etiology.
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DOI: http://dx.doi.org/10.19166/med.v10i1.6993
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1. Molecular Imaging: The Requisites. 5th ed. Philadelphia: Elsevier; 2021; 75-124.
2. Ghostine B, Sebaaly A, Ghanem I. Multifocal metachronous giant cell tumor: case report and review of the literature. Case Rep Med. 2014;2014:678035. https://doi.org/10.1155/2014/678035
3. Morey V, Sankineani SR, Kumar R. Multifocal metachronous giant cell tumour in bilateral upper limb: a rare case presentation. Musculoskelet Surg. 2014;98(2):165-9. https://doi.org/10.1007/s12306-012-0223-2
4. Lalam R, Bloem JL, Noebauer-Huhmann IM, Wortler K, Tagliafico A, Vanhoenacker F, et al. ESSR Consensus Document for Detection, Characterization, and Referral Pathway for Tumors and Tumorlike Lesions of Bone. Semin Musculoskelet Radiol. 2017;21(5):630-47. https://doi.org/10.1055/s-0037-1606130
5. Panagopoulos A, Tatani I, Kourea HP, Kokkalis ZT, Panagopoulos K, Megas P. Osteolytic lesions (brown tumors) of primary hyperparathyroidism misdiagnosed as multifocal giant cell tumor of the distal ulna and radius: a case report. J Med Case Rep. 2018;12(1):176. https://doi.org/10.1186/s13256-018-1723-y
6. Gosavi S, Kaur H, Gandhi P. Multifocal osteolytic lesions of jaw as a road map to diagnosis of brown tumor of hyperparathyroidism: A rare case report with review of literature. J Oral Maxillofac Pathol. 2020;24(Suppl 1):S59-S66. https://doi.org/10.4103/jomfp.JOMFP_319_19
7. Elgazzar AH. Parathyroid Gland. Dalam: Elgazzar AH, editor. The Pathophysiologic Basis of Nuclear Medicine. 2nd ed. Verlag-Berlin Heidelberg: Springer; 2006; 222-37. https://doi.org/10.1007/978-3-540-47953-6_8
8. El Demellawy D, Davila J, Shaw A, Nasr Y. Brief Review on Metabolic Bone Disease. Acad Forensic Pathol. 2018;8(3):611-40. https://doi.org/10.1177/1925362118797737
9. Elgazzar AH. Diagnosis of Metabolic, Endocrine, and Congenital Bone Disease. Dalam: Elgazzar AH, editor. Orthopedic Nuclear Medicine;10.1007/978-3-319-56167-7. 2nd ed. Switzerland: Springer 2017; 101-45. https://doi.org/10.1007/978-3-319-56167-7_3
10. Elgazzar AH. Basic Sciences of Bone and Joint Diseases. Dalam: Elgazzar AH, editor. Orthopedic Nuclear Medicine;10.1007/978-3-319-56167-7. 2th ed. Verlag Berlin Heidelberg: Springer; 2017; 1-36. https://doi.org/10.1007/978-3-319-56167-7_1
11. O'Malley JP, Ziessman HA. Endocrine System. Dalam: Thrall JH, editor. Nuclear Medicine and Molecular Imaging: The Requisites 5th ed. Philadelphia: Elsevier; 2021;152-79.
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