.png)
Characteristics of NSAIDs Prescription in Elderly Knee Osteoarthritis Patients
Abstract
Introduction: The prescribing of non-steroidal anti-inflammatory drugs (NSAIDs) as pharmacological therapy for OA was found to be imprecise. In 2018, the rationality of NSAIDs prescribed at Wolter Monginsidi Hospital, Manado showed as much as 100% proper indication, 77% proper dose, and 89% proper medication. This shows that the rationality of NSAIDs prescription is still irrational. Irrational prescribing has the potential to result in side effects or the incidence of drug-related problems
Aim: To determine the characteristics and the rationality of NSAIDs prescriptions in elderly knee OA.
Methods: This is a descriptive study of 108 medical records for the period January 2020-April 2021 at BS Clinic, Semarang, using purposive sampling method.
Result: Results showed the characteristics of elderly knee OA patients at BS Clinic were 74.1% women, 47.2% belonging to obese group, and 41.7% experiencing severe pain. Patient’s age had a median value of 66 years. In the number of comorbidity, the median value was 1. The rationality of NSAIDs prescription was 95,4% proper diagnosis, 100% proper drug, 97.2% proper dose, and 99.1% proper indication with the incidence of side effects of NSAIDs prescribing was 1.9%.
Keywords
DOI: http://dx.doi.org/10.19166/med.v10i1.6988
Full Text:
PDFReferences
1. World Health Organization. Health in Older Age. In: World Report on Ageing and Health. 2015.
2. UU 13/1998. Undang-Undang No 13 Tahun 1998. Mensesneg 1999 p. 1-2.
3. Maylasari I, Rachmawati Y, Wilson H, Nugroho S, Sulistyowati N, Dewi F. Demografi. In: Statistik Penduduk Lanjut Usia di Indonesia. 2019.
4. Kolasinski SL, Neogi T, Hochberg MC, Oatis C, Guyatt G, Block J, et al. 2019 American College of Rheumatology/Arthritis Foundation Guideline for the Management of Osteoarthritis of the Hand, Hip, and Knee. Arthritis Care and Research. 2020;72(2):149-62. https://doi.org/10.1002/acr.24131
5. Departemen Farmakologi dan Terapeutik Fakultas Kedokteran Universitas Indonesia. Analgesik-Antipiretik Analgesik Anti-Inflamasi Nonsteroid dan Obat Gangguan Sendi Lainnya. In: Farmakologi dan Terapi. 6th ed. Jakarta: Badan Penerbit FKUI; 2016.
6. Kementrian Kesehatan RI. Penggunaan Obat yang Rasional dalam Praktek. In: Kementerian Kesehatan RI. 2011. p. 1-192.
7. Isngadi SNIP. Evaluasi Penggunaan Obat NSAID pada Pasien Osteoarthritis Rawat Jalan di RS TNI AD Robert Wolter Monginsidi Manado. 2018;
8. Ramadhan RI. Rasionalitas Penggunaan OAINS pada Pasien Reumatik Osteoarthritis Rawat Jalan di RSUD Kabupaten Subang Tahun 2014 Ditinjau dari (Tepat Diagnosis, Tepat Dosis, Tepat Cara Pemberian, Tepat Pasien). 2015. 9.
9. Wongrakpanich S, Wongrakpanich A, Melhado K, Rangaswami J. A comprehensive review of non-steroidal anti-inflammatory drug use in the elderly. Aging and Disease. 2018;9(1):143-50. https://doi.org/10.14336/AD.2017.0306
10. Maniar KH, Jones IA, Gopalakrishna R, Vangsness CT. Lowering side effects of NSAID usage in osteoarthritis: recent attempts at minimizing dosage. Expert Opinion on Pharmacotherapy. 2018;19(2):93-102. https://doi.org/10.1080/14656566.2017.1414802
11. Dewi DNSSD, Amanda NA, Sasono B. Faktor Dominan pada Penderita Osteoartritis di RSUD dr. Mohamad Soewandhie, Surabaya, Indonesia. Jurnal Medika Udayana. 2020;9(11):1- 7
12. Dieppe P, Blom A. Osteoarthritis. In: Blom A, Warwick D, Whitehouse Mi, editors. Apley & Solomon's System of Orthopaedics and Trauma. 10th ed. CRC Press Taylor & Francis Group; 2018. p. 91-105.
13. Thati S. Gender Differences in Osteoarthritis of Knee: An Indian Perspective. J Midlife Health. 2021;16-20. https://doi.org/10.4103/jmh.jmh_35_21
14. Spitaels D, Mamouris P, Vaes B, Smeets M, Luyten F, Hermens R, et al. Epidemiology of knee osteoarthritis in general practice: a registry-based study. BMJ Open. 2020;10(1):1-9. https://doi.org/10.1136/bmjopen-2019-031734
15. Bihlet AR, Byrjalsen I, Bay-Jensen AC, Andersen JR, Christiansen C, Riis BJ, et al. Associations between biomarkers of bone and cartilage turnover, gender, pain categories and radiographic severity in knee osteoarthritis. Arthritis Research and Therapy. 2019;21(1):1-10. https://doi.org/10.1186/s13075-019-1987-7
16. Febiantika T. Hubungan IMT dengan Resiko Kejadian Osteoartritis Genu pada Wanita Usia 60-70 Tahun di Posyandu Lansia. 2018;5-6.
17. Mutiwara E, Najirman N, Afriwardi A. Hubungan Indeks Massa Tubuh dengan Derajat Kerusakan Sendi pada Pasien Osteoartritis Lutut di RSUP Dr. M. Djamil Padang. Jurnal Kesehatan Andalas. 2016;5(2):376-80. https://doi.org/10.25077/jka.v5i2.525
18. Hasiibi W. Prevalensi Dan Distribusi Osteoartritis Lutut Berdasarkan Karakteristik Sosio- Demografi Dan Faktor Risiko Di Wilayah Kerja Puskesmas Susut I, Kecamatan Susut, Kabupaten Bangli Pada Tahun 2014. Intisari Sains Medis. 2015;4(1):32-41. https://doi.org/10.15562/ism.v4i1.47
19. Hügle T, Geurts J, Nüesch C, Müller-Gerbl M, Valderrabano V. Aging and osteoarthritis: An inevitable encounter? Journal of Aging Research. 2012;2012. https://doi.org/10.1155/2012/950192
20. Li YS, Xiao W feng, Luo W. Cellular aging towards osteoarthritis. Mechanisms of Ageing and Development. 2017;162:80-4. https://doi.org/10.1016/j.mad.2016.12.012
21. Murphy LB, Hootman JM, Boring MA, Carlson SA, Qin J, Barbour KE, et al. Leisure Time Physical Activity Among U.S. Adults With Arthritis, 2008−2015. American Journal of Preventive Medicine. 2017;53(3):345-54. https://doi.org/10.1016/j.amepre.2017.03.017
22. Sun Z. Aging, Arterial Stiffness, and Hypertension. AHA Journals. 2015;65(2):252-6. https://doi.org/10.1161/HYPERTENSIONAHA.114.03617
23. Altman R, Bosch B, Brune K, Patrignani P, Young C. Advances in NSAID development: Evolution of diclofenac products using pharmaceutical technology. Drugs. 2015;75(8):859-77. https://doi.org/10.1007/s40265-015-0392-z
24. Alghadir AH, Anwer S, Iqbal A, Iqbal ZA. Test-retest reliability, validity, and minimum detectable change of visual analog, numerical rating, and verbal rating scales for measurement of osteoarthritic knee pain. Journal of Pain Research. 2018;11:851-6. https://doi.org/10.2147/JPR.S158847
25. Thong ISK, Jensen MP, Miró J, Tan G. The validity of pain intensity measures: What do the NRS, VAS, VRS, and FPS-R measure? Scandinavian Journal of Pain. 2018;18(1):99-107. https://doi.org/10.1515/sjpain-2018-0012
26. Gallasch CH, Alexandre NMC. The measurement of musculoskeletal pain intensity: a comparison of four methods. Revista Gaúcha de Enfermagem. 2007;28(2):260-5.
27. Abari IS. 2016 ACR Revised Criteria for Early Diagnosis of Knee Osteoarthritis. Autoimmune Disease and Theraupeutic Approaches. 2016;3(February):1.
28. Paskins Z, Sanders T, Croft PR, Hassell AB. The identity crisis of osteoarthritis in general practice: A qualitative study using video-stimulated recall. Annals of Family Medicine. 2015;13(6):537-44. https://doi.org/10.1370/afm.1866
29. Egerton T, Nelligan RK, Setchell J, Atkins L, Bennell KL. General Practitioners' Views on Managing Knee Osteoarthritis: A Thematic Analysis of Factors Influencing Clinical Practice Guideline Implementation in Primary Care. BMC Rheumatology. 2018;2(1):1-11. https://doi.org/10.1186/s41927-018-0037-4
30. Egerton T, Diamond LE, Buchbinder R, Bennell KL, Slade SC. A systematic review and evidence synthesis of qualitative studies to identify primary care clinicians' barriers and enablers to the management of osteoarthritis. Osteoarthritis and Cartilage. 2017;25(5):625-38. https://doi.org/10.1016/j.joca.2016.12.002
31. Lau R, Stevenson F, Ong BN, Dziedzic K, Treweek S, Eldridge S, et al. Achieving change in primary care-causes of the evidence to practice gap: Systematic reviews of reviews. Implementation Science. 2016;11(1). https://doi.org/10.1186/s13012-016-0396-4
32. Hanifah IL. Rasionalitas Penggunaan Obat Osteoartritis Pada Pasien Osteoartritis Di Instalasi Rawat Jalan Rsup Dr. Soeradji Tirtonegoro Klaten Tahun 2018. CoreAcUk [Internet]. 2019; https://doi.org/10.21111/pharmasipha.v3i2.3404
33. Park K, Bavry AA. Risk of stroke associated with nonsteroidal anti-inflammatory drugs. Vascular Health and Risk Management. 2014;10:25-32. https://doi.org/10.2147/VHRM.S54159
34. al Khaja KAJ, Veeramuthu S, Isa HA, Sequeira RP. Prescription audit of NSAIDs and gastroprotective strategy in elderly in primary care. International Journal of Risk and Safety in Medicine. 2017;29(1-2):57-68. https://doi.org/10.3233/JRS-170742
35. Kanno T, Moayyedi P. Who Needs Gastroprotection in 2020? Current Treatment Options in Gastroenterology. 2020;18(4):557-73. https://doi.org/10.1007/s11938-020-00316-9
36. Lanza FL, Chan FKL, Quigley EMM, Inadomi J, Baroni D, Bernstein D, et al. Guidelines for prevention of NSAID-related ulcer complications. American Journal of Gastroenterology. 2009;104(3):728-38. https://doi.org/10.14309/00000434-200903000-00035
37. Gwee KA, Goh V, Lima G, Setia S. Coprescribing proton-pump inhibitors with nonsteroidal anti-inflammatory drugs: Risks versus benefits. Journal of Pain Research. 2018;11:361-74. https://doi.org/10.2147/JPR.S156938
38. Bjarnason I, Scarpignato C, Holmgren E, Olszewski M, Rainsford KD, Lanas A. Mechanisms of Damage to the Gastrointestinal Tract From Nonsteroidal Anti-Inflammatory Drugs. Gastroenterology. 2018;154(3):500-14. https://doi.org/10.1053/j.gastro.2017.10.049
Refbacks
- There are currently no refbacks.
Copyright (c) 2022 Janetta Wong, Nicolaski Lumbuun
This work is licensed under a Creative Commons Attribution-ShareAlike 4.0 International License.
MEDICINUS is licensed under a Creative Commons Attribution-ShareAlike 4.0 International License. Copyright © Fakultas Kedokteran | Universitas Pelita Harapan | Lippo Karawaci, Tangerang, Indonesia, 15811 . All rights reserved. p-ISSN 1978-3094 | e-ISSN 2622-6995