.png)
Epilepsi Dalam Kehamilan
Abstract
Epilepsi merupakan salah satu kondisi neurologis yang paling sering ditemukan pada ibu hamil, dengan prevalensi 0,5-1%. Telah dilaporkan bahwa sebanyak 12 dari 14 kasus kematian ibu yang terjadi sejak tahun 2009 hingga 2012, diklasifikasikan sebagai sudden unexpected death in epilepsy atau SUDEP dengan kondisi kejang yang tidak terkontrol dengan baik yang merupakan faktor penyebab utama. Perubahan fisiologis selama kehamilan dapat berpengaruh terhadap farmakokinetik dari obat antiepileptik sehingga dapat menimbulkan bangkitan kejang pada wanita dengan epilepsi yang sedang hamil. Angka kejadian fetal loss akibat pengaruh epilepsi atau obat antiepileptik cenderung rendah. Pengaruh obat antiepileptik terhadap kehamilan dapat berakibat pada malformasi kongenital mayor, perkembangan neurokognitif yang terganggu, risiko obstetrik, dan komplikasi perinatal.
Keywords
DOI: http://dx.doi.org/10.19166/med.v7i2.1796
Full Text:
PDFReferences
Royal College of Obstetrician and Gynecologists. Epilepsy in Pregnancy: Green Top Guideline No. 68. NICE 2016; 68: p8-27.
Harden CL. Management Issues for Women with Epilepsy- Focus on Pregnancy: Obstetrical Complications and Change in Seizure Frequency. Epilepsia 2009: 50(5): 1229-1336.
Yerby, M.S. Quality of Life, Epilepsy Advances, And The Evolving Role of Anticonvulsants In Women With Epilepsy. Neurology 2000; 55: S23–S31.
International League Against Epilepsy. Epilepsy 2015 From Channels to Commisioning: A Practical Guide to Epilepsy. East Sussex: ILAE UK and Epilepsy Society. 2015.
Shorvon SD. The Etiologic Classificaiton of Epilepsy. Epilepsia 52(6): 1052-1057. 2011.
Fisher RS, Cross H, French JA, et al. Operational Classfication of Seizure Types by the International League Against Epilepsy. Stanford. 2016.
Lowenstein DH. Seizure and Epilepsy: In Harrison’s Neurology in Clinical Medicine. 3rd ed. McGrawHill. 2013. p 231-256.
Gunadharma S, Kustiowati E, Husna M. Terapi: In Kelompok Studi Epilepsi PERDOSSI. Pedoman Tatalaksana Epilepsi. 5th ed. Surabaya: Airlangga University Press. 2014.
Patel SI, Pennell PB. Management of Epilepsy During Pregnancy: an update. Ther Adv Neurol Disord 2016, Vol. 9(2) 118–129
Thomas SV. Management of Epilepsy and Pregnancy. J Postgrad Med 2006: 52(1):57-64.
Battino, D., Tomson, T., Bonizzoni, E., Craig, J., Lindhout, D., Sabers, A. et al. Seizure Control and Treatment Changes in Pregnancy: Observations from the EURAP Epilepsy Pregnancy Registry. Epilepsia 2013; 54: 1621–1627.
Reisinger, T., Newman, M., Loring, D., Pennell, P. and Meador, K. Antiepileptic Drug Clearance and Seizure Frequency During Pregnancy in Women with Epilepsy. Epilepsy Behav 2003: 29: 13–18.
Ropper AH, Samuels MA, Klein JP. Adams and Victor’s Principles of Neurology. 10th ed. McGrawHill: 2014.p318-356.
Cunningham FG, Leveno KJ, Spong CY, et al. Williams Obstetrics. 24th ed. McGrawhill 2014: p1189-1191.
Manthey, D., Asimiadou, S., Stefovska, V., Kaindl A.M., Fassbender J., Ikonomidou C. et al. Sulthiame but Not Levetiracetam Exerts Neurotoxic Effect in The Developing Rat Brain. Exp Neurol 2005; 193: 497–503.
Pennell, P., Peng, L., Newport, D., Ritchie, J., Koganti, A., Holley, D. et al. Lamotrigine in Pregnancy: Clearance, Therapeutic Drug Monitoring, And Seizure Frequency. Neurology 2008:70: 2130–2136.
Artama, M., Gissler, M., Malm, H., Ritvanen, A. and the Drug & Pregnancy Group. Effects of Maternal Epilepsy and Antiepileptic Drug Use During Pregnancy On Perinatal Health In Offspring: Nationwide, Retrospective Cohort Study In Finland. Drug Saf 2013; 36: 359–369.
Borthen, I., Eide, M., Veiby, G., Daltveit, A. and Gilhus, N. Complications During Pregnancy in Women with Epilepsy: Population-Based Cohort Study. BJOG 2009;116: 1736–1742.
SA Maternal and Neonatal Clinical Network. Policy Clinical Guideline Epilepsy and pregnancy management. Department for Health and Aging, Government of South Australia. 2014; p1-13.
Mirawati DK, Winifred K, Frida M. Epilepsi pada Perempuan: In Kelompok Studi Epilepsi PERDOSSI. Pedoman Tatalaksana Epilepsi. 5th ed. Surabaya: Airlangga University Press. 2014.
Walker SP, Permezel M, Berkovic SF. The Management of Epilepsy in Pregnancy. BJOG 2009: 116: 758-767.
Adab N, Chadwick DW. Review Management of Women with Epilepsy During Pregnancy. The Obstetrician & Gynaecologist 2006; 8:20–25.
Refbacks
- There are currently no refbacks.
Copyright (c) 2019 Fidelia Fidelia, Julita D L Nainggolan
This work is licensed under a Creative Commons Attribution-ShareAlike 4.0 International License.
MEDICINUS is licensed under a Creative Commons Attribution-ShareAlike 4.0 International License. Copyright © Fakultas Kedokteran | Universitas Pelita Harapan | Lippo Karawaci, Tangerang, Indonesia, 15811 . All rights reserved. p-ISSN 1978-3094 | e-ISSN 2622-6995