Kemampuan Regenerasi Planaria Ditinjau Melalui Sistem Kerja Sel Neoblast dan Mekanisme Persinyalan

Authors

  • Clement Khristman Laia Program Studi Pendidikan Biologi, Fakultas Ilmu Pendidikan, Universitas Pelita Harapan
  • Mutiara Yaemeliza Venderry Giri Program Studi Pendidikan Biologi, Fakultas Ilmu Pendidikan, Universitas Pelita Harapan
  • Wahyu Irawati Program Studi Pendidikan Biologi, Fakultas Ilmu Pendidikan, Universitas Pelita Harapan

Abstract

Planaria have extraordinary regenerative abilities. Adult planarians can regenerate almost all lost tissue through the activity of large numbers of parenchymal cells called neoblasts. Neoblasts are a population of mature cells that actively divide and collectively produce other types of mature cells. This research aims to determine the working system of neoblast cells and the potential for utilizing Wnt/β-catenin signals in the field of biotechnology. The method used is literature study by collecting, analyzing and synthesizing information from relevant literature studies. Neoblasts respond to injury by increasing their rate of proliferation. The peak of the initial proliferative response will increase after 6 hours of injury followed by a proliferation phase that continues around the wound after 48 hours. In the planarian regeneration process, there is a special signaling mechanism, namely Wnt/β-catenin. This signaling pathway has enormous potential to be utilized in the field of biotechnology, especially in the development of drug research because it has very complex polarity, the presence of bioelectric signals, and the ability to activate genetic pathways.

 

References

Adler, C. E., & Alvarado, A. S. (2015). Types or states? Cellular dynamics and regenerative potential. Trends in Cell Biology, 25(11), 687-696.

Andrika, W. (2021). Pengembangan Modul Praktikum Filum Platyhelmintes Pada Proses Fragmentasi Sebagai Penunjang Praktikum Mata Kuliah Zoologi Invertebrata (Doctoral dissertation, UIN Ar-Raniry).

Attika, C., Zulfa, C. S., Atifah, Y., & Achyar, A. (2021, September). Pengaruh bagian potongan tubuh terhadap pertumbuhan dan kecepatan daya regenerasi pada Euplanaria sp.(Planaria). In Prosiding Seminar Nasional Biologi (Vol. 1, No. 1, pp. 5-6).

Azwar, H. N. (2021). Keanekaragaman makrozoobentos di aliran Sungai Coban Rais, Coban Putri dan Kali Ampo Kota Batu (Doctoral dissertation, Universitas Islam Negeri Maulana Malik Ibrahim).

AULIA, R. (2020). Pengaruh Pembelajaran Berbantuan Smartphone terhadap Motivasi dan Hasil Belajar Siswa pada Materi Sistem Eksresi Kelas XI IPA SMAN 3 Jember Tahun Pelajaran 2019/2020 (Doctoral dissertation, Fakultas Tarbiyah dan Ilmu Keguruan Program Studi Tadris Biologi).

Baguñà , J. (1976). Mitosis in the intact and regenerating planarian Dugesia mediterranea n. sp. I. Mitotic studies during growth, feeding and starvation. Journal of Experimental Zoology, 195(1), 53-64.

Baguñà , J. (2012). The planarian neoblast: the rambling history of its origin and some current black boxes. International Journal of Developmental Biology, 56(1-2-3), 19-37.

Cahyanurani, A. B., Rizky, P. N., Putri, N. T., Safitri, N. M., Fathurrohim, M. F., Zen, S., ... & Muamar, A. (2023). Avertebrata Air. Global Eksekutif Teknologi.

De Miguel-Bonet, M. D. M., Ahad, S., & Hartenstein, V. (2018). Role of neoblasts in the patterned postembryonic growth of the platyhelminth Macrostomum lignano. Neurogenesis, 5(1), e1469944.

Elliott, S. A., & Sánchez Alvarado, A. (2013). The history and enduring contributions of planarians to the study of animal regeneration. Wiley Interdisciplinary Reviews: Developmental Biology, 2(3), 301-326.

Eugenin, E. A., Basilio, D., Sáez, J. C., Orellana, J. A., Raine, C. S., Bukauskas, F., ... & Berman, J. W. (2012). The role of gap junction channels during physiologic and pathologic conditions of the human central nervous system. Journal of Neuroimmune Pharmacology, 7, 499-518.

Ge, X. Y., Han, X., Zhao, Y. L., Cui, G. S., & Yang, Y. G. (2022). An insight into planarian regeneration. Cell Proliferation, 55(9), e13276.

González-Estévez, C., Felix, D. A., Rodríguez-Esteban, G., & Aboobaker, A. A. (2012). Decreased neoblast progeny and increased cell death during starvation-induced planarian degrowth. International Journal of Developmental Biology, 56(1-2-3), 83-91.

Hiebert, L. S., Simpson, C., & Tiozzo, S. (2021). Coloniality, clonality, and modularity in animals: The elephant in the room. Journal of Experimental Zoology Part B: Molecular and Developmental Evolution, 336(3), 198-211.

Ismail, S. (2019). Mikrobiologi-Parasitologi. Deepublish.

KALSUM, U., & Hanim, I. (2022). BIOLOGI UNTUK SMA/MA KELAS X SEMESTER 2. Penerbit P4I.

Leu, P. L., Naharia, O., Moko, E. M., Yalindua, A., & Ngangi, J. (2021). Karakter Morfologi dan Identifikasi Hama pada Tanaman Dalugha (Cyrtosperma merkusii (Hassk.) Schott) di Kabupaten Kepulauan Talaud Propinsi Sulawesi Utara. Jurnal ilmiah sains, 21(1), 96-112.

Lewallen, M., & Burggren, W. (2020). Metabolic physiology of the freshwater Planaria Girardia dorotocephela and Schmidtea mediterranea: Reproductive mode, specific dynamic action, and temperature. American Journal of Physiology-Regulatory, Integrative and Comparative Physiology, 319(4), R428-R438.

LoCascio, S. A., Lapan, S. W., & Reddien, P. W. (2017). Eye absence does not regulate planarian stem cells during eye regeneration. Developmental Cell, 40(4), 381-391.

Palupi, E. S., Sari, I. A. A. R. P., & Wibowo, E. S. (2015). Tahapan Perkembangan Organ Reproduksi Seksual Planaria dari Perairan Lereng Gunung Slamet, Baturraden, Banyumas. Sains dan Matematika, 3(2).

PRATIWI, A. (2019). IDENTIFIKASI MAKROZOOBENTHOS SEBAGAI BIOINDIKATOR UNTUK MENENTUKAN STATUS LINGKUNGAN SITU BAGENDIT KABUPATEN GARUT (Doctoral dissertation, FKIP UNPAS).

Roberts-Galbraith, R. H., & Newmark, P. A. (2015). On the organ trail: insights into organ regeneration in the planarian. Current opinion in genetics & development, 32, 37-46.

Sarnat, H. B., & Netsky, M. G. (1985). The brain of the planarian as the ancestor of the human brain. Canadian Journal of Neurological Sciences, 12(4), 296-302.

Surtikanti, H. K., & Bahabazi, U. (2013). Studi Tentang Ekologi dan Habitat Planaria, Sp. di Subang: Kelimpahan dan Biomassa Merupakan Indikator Kualitas Air Bersih. Majalah Ilmiah Biologi BIOSFERA: A Scientific Journal, 30(2), 66-72.

Saputri, M. M., & Ami, M. S. (2021). Biologi. LPPM Universitas KH. A. Wahab Hasbullah.

Surtikanti, H. K. (2010). Pemeliharaan Planaria Dalam Perkembangbiakan Secara Vegetatif. Biota: Jurnal Ilmiah Ilmu-Ilmu Hayati, 80-84.

Tian, Q., Sun, Y., Gao, T., Li, J., Hao, Z., Fang, H., & Zhang, S. (2021). TBX2/3 is required for regeneration of dorsal”ventral and medial”lateral polarity in planarians. Journal of Cellular Biochemistry, 122(7), 731-738.

Yasilda, B. P. (2022). IDENTIFIKASI JENIS-JENIS PERILAKU HEWAN VERTEBRATA DAN INVERTEBRATA (Doctoral dissertation, UIN RADEN INTAN LAMPUNG).

Yohannes, B. Y., Utomo, S. W., & Agustina, H. (2019). Kajian Kualitas Air Sungai dan Upaya Pengendalian Pencemaran Air. IJEEM-Indonesian Journal of Environmental Education and Management, 4(2), 136-155.

Wahyuningsih, E., Rahayu, N. L., & Zaenuri, M. (2022). Pengaruh Penambangan Batu Terhadap Komunitas Makrozoobentos di Sungai Logawa. Jurnal Multidisiplin Madani, 2(2), 1047-1066.

Barata, G., Gama, S., Jorge, J., & Gonçalves, D. (2013). Improving Participation and Learning with Gamification. Proceedings of the First International Conference on Gameful Design, Research, and Applications (pp. 10-17). Gamification 2013. doi: 10.1145/2583008.2583010

Downloads

Published

2025-07-15

Issue

Vol. 2 No. 1 (2025): BioActive

Section

Articles

License

Copyright (c) 2025 BioActive: Journal of Biological Education and Research

Creative Commons License

This work is licensed under a Creative Commons Attribution-ShareAlike 4.0 International License.