THE ROLE OF RADIOTHERAPY IN UTERINE CERVICAL CANCER

Authors

  • Henry Kodrat Fakultas Kedokteran Universitas Pelita Harapan, Karawaci, Indonesia

DOI:

https://doi.org/10.19166/med.v5i1.1179

Abstract

Uterine cervical cancer is the most common cancer in Indonesia. The purpose of the review is to describe diagnosis and staging, the basic principles of radiotherapy, the role of radiotherapy in cervical cancer treatment, and radiotherapy side effects. The goal of radiotherapy in cervical cancer consists of definitive, adjuvant, and palliative. Effort to increase radiation response also develops by administered small dose of chemotherapy as a radiosensitizer.

Keywords: cancer, cervix, radiotherapy

References

Franco EL, Schecht NF, Saslow D. The epidemiology of cervical cancer. Cancer J 2003; 9(5): 348-359.

Perez CA, Kavangh BD. Uterine cervix. In: Perez CA, Brady LW, Halperin EC (ed). Perez and Brady’s principles and practice of radiation oncology 5th ed. Philadelphia: Lippincott Williams & Wilkins; 2008: p. 1533-1595.

Aziz FA. Gynecological cancer in Indonesia. J Gynecol Oncol 2009; 20(1): 8-10.

Tjindarbumi D, Mangunkusumo R. Cancer in Indonesia, present and future. Jpn J Clin Oncol 2002; 32: s17-s21.

Garland SM, Bhatala N, Ngan HYS. Cervical cancer burden and prevention strategies: asia oceania prespective. Cancer Epidemiol Biomarkers Prev 2012; 21: 1414-1422.

Colombo N, Carinelli S, Colombo A, Marini C, Rollo D, Sessa C. Cervical cancer: ESMO clinical practice guideline for diagnosis, treatment and follow-up. Ann Oncol 2012; 23: s27-s32.

Zeng J, Lin L. Cervical cancer. In: Hristov B, Lin SH, Christodouleas JP (ed). Radiation oncology; a question-based review. Philadephia: Lippincott William & Wilkins 2011, p. 419-428.

Kim SM, Choi HS, Byun JS. Overall 5-year survival rate and prognostic factors in patient with stage IB and IIA cervical cancer treated with radical hysterectomy and pelvic node dissection. Int J Gynecol Oncol 2000; 10: 305-312.

Halperin EC, Perez CA, Brady LW. The discipline of radiation oncology. In: Perez and Brady’s principles and practice of radiation oncology. 5th ed. Philadelphia: Lippincott Williams & Wilkins. 2008. p. 1-75.

Beyzadeoglu M, Ebruli C, Ozyigit G. Clinical radiation oncology. In: Beyzadeoglu M, Ozyigit G, Ebruli C. Basic radiation oncology. Heidelberg: Springer; 2010. p. 145-174.

Barrett A, Dobbs J, Morris S, Roques T. Principles of brachytherapy. In: Barrett A, Dobbs J, Morris S, Roques T. Practical radiotherapy planning. 4th ed. London: Hodder Arnold, 2009. p. 54-61.

Bermudez RS, Huang K, Hsu IC. Cervical cancer. In: Hansen EK, Roach M (ed). Handbook of Evidence-Based Radiation Oncology 2nd ed. New York; Springer; 2010. p. 496-512.

Rotman M, Sedlis A, Piedmonte MR, Bundy B, Lentz SS, Muderspach LI et al. A phase III randomized trial of postoperative pelvic irradiation in stage IB cervical carcinoma with poor prognostic feature: follow up of gynecology oncology group study. Int J Radiat Oncol Biol Phys 2006; 65: 169-176.

Peters WA III, Liu PY, Barrett RJ, Stock RJ, Monk BJ, Berek JS et al. Concurrent chemotherapy and pelvic radiation therapy compared with pelvic radiation therapy alone as adjunctive therapy after radical surgery in high-risk early-stage cancer of the cervix. J Clin Oncol 2000; 18: 1606-1613.

Taylor A, Powell MEB. Intensity modulated radiotherapy-what is it? Cancer Imag 2004; 4: 68-73.

D’Souza DP, Rumble RB, Fylesz A, Yaremko B, Warde P. Intensity modulated radiotherapy in the treatment of gynecological cancers. Clin Oncol 2012; 24: 499-507.

Gerbaulet A, Potter R, Meder CH. Cervix carcinoma. In: Gerbaulet A, Puller C, Mazeron JJ, Meertens H, Umbergen EV (ed). The GEC ESTRO handbook of brachytherapy. Leuven: ESTRO; 2002. p. 301-364.

Rose PG, Ali S, Watkins E et al (2007) Long-term follow-up of a randomized trial comparing concurrent single agent cisplatin, cisplatinbased combination chemotherapy, or hydroxyurea during pelvic irradiation for locally advanced cervical cancer: a Gynecologic Oncology Group Study. J Clin Oncol 2007; 25: 2804-2810.

Eifel PJ, Winter K, Morris M, Levenback C, Grigsby PW, Cooper J et al. Pelvic irradiation with concurrent chemotherapy versus pelvic and para-aortic irradiation for high-risk cervical cancer: an update of radiation oncology group trial (RTOG) 90-01. J Clin Oncol 2004; 22: 872-880.

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Published

2018-08-09

Issue

Vol. 5 No. 1 (2015): October 2015 - January 2016

Section

Review Article

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