Clinical Characteristic of Young Indonesian Colorectal Cancer Patients: A Preliminary Study

Nata Pratama Lugito


Introduction: Colorectal cancer (CRC) is generally a disease of persons aged above 40 year-old. Controversies still exist regarding clinical characteristics of CRC in young persons. The aim of this study is to know the clinical characteristics of young CRC patients in Siloam General Hospital, Karawaci, Banten.

Material And Methods: A total of 14 patients with diagnosis of CRC from December 2013 to January 2014 in Siloam General Hospital, Karawaci, Banten were studied cross – sectionally.  The symptoms and signs, family history of cancer, diabetes, location of mass were collected and evaluated.

Results: There were 5 (35.7%) cases of CRC patients aged below 40 year-old (young patients) and 9 (64.3%) above 40 years-old (old patients). The most common symptom was constipation followed by bloody diarrhea i.e. 57.1% and 42.9% consecutively. Constipation occurred in 2 and 6 young and old patients consecutively and in 3 and 3 young and old patients consecutively. In young patients, 2 (14.2%) had a history of cancer in the family compared to none in the old patients. According to the location of tumor in the colon 4 (28.5%) were in ascending colon with 2 and 2 in young and old patients consecutively, 3 (21.7%) were in descending colon with 2 and 1 in young and old patients consecutively, 8 (57.1%) were in rectum with 2 and 6 in young and old patients consecutively. One young patient had diabetes, and one other young patient had positive Clostridium difficile antigen and toxin.

Conclusion: Approximately 35.7% cases CRC patient in our hospital was of young patients. Two patients were having family history of cancer. The location of mass was not specific for young CRC patients.

Key words: colorectal cancer, young patients


Full Text:




Edwards BK, Ward E, Kohler BA, Eheman C, Zauber AG, Annual report to the nation on the status of cancer, 1975-2006, featuring CRC trends and impact of interventions (risk factors, screening, and treatment) to reduce future rates. Cancer 2010; 116: 544-73

You YN, Xing Y, Feig BW, Chang GJ, Cormier JN. Young onset CRC: is it time to pay attention? Arch Intern Med 2012; 172: 287-9.

Chung YF, Eu KW, Machin D, Ho JM. Young age is not a poor prognostic marker in colorectal cancer. Br J Surg. 1998;85(9):1255-9.

Cusack JC, Giacco GG, Cleary K, Davidson BS. Survival factors in 186 patients younger than 40 years old with colorectal adenocarcinoma. J Am Coll Surg. 1996;183(2):105-12

Neufeld D, Shpitz B, Bugaev N, Grankin M, Bernheim J, Young-age onset of CRC in Israel. Tech Coloproctol 2009; 13: 201-204

McMillan DC, McArdle CS. The impact of young age on cancer-specific and non-cancer-related survival after surgery for CRC: 10-year follow-up. Br J Cancer 2009; 101: 557-60

Jian-Fei F, Yan-Qin H, Jiao Y, Cheng-Hao Y, Hai-Long C, Clinical characteristics and prognosis of young patients with CRC in Eastern China. World J Gastroenterol 2013; 19(44): 8078-84.

Sander MA. Profile of CRC At Hasan Sadikin Hospital Bandung. Fakultas Kedokteran Universitas Muhammadiyah Malang. 2006.

José AS, Jimenez AAB, García-Alhambra BMA, Pla AR, Vidán BM, Differences In The Therapeutic Approach To CRC In Young And Elderly Patients. The Oncologist 2012;17:1277–85.

Bouassida M, Feidi B, Mroua B, Chtourou MF, Sassi S, Histopathologic characteristics and short-term outcomes of CRC in young Tunisian patients: one center’s experience. Pan African Medical Journal. 2012; 12:10

Sobhani I, Tap J, Roudot-Thoraval F, Roperch JP, Letulle S, Microbial dysbiosis in colorectal cancer (CRC) patients. PLos One 2011;6: e16393.

Shen XJ, Rawls JF, Randall T, Burcal L, Mpande CN, Jenkins N, Jovov B, Abdo Z, Sandler RS, Keku TO. Molecular characterization of mucosal adherent bacteria and associations with colorectal adenomas. Gut Microbes 2010;1: 138–47.

Scanlan PD, Shanahan F, Clune Y , Collins JK, O'Sullivan GC, Culture-independent analysis of the gut microbiota in colorectal cancer and polyposis. Environ Microbiol 2008;10: 789–98.


  • There are currently no refbacks.

Copyright (c) 2018 Nata Pratama Lugito

Creative Commons License
This work is licensed under a Creative Commons Attribution-ShareAlike 4.0 International License.

favicon Fakultas Kedokteran | Universitas Pelita Harapan | Lippo Karawaci, Tangerang, Indonesia, 15811